Category: Adjunctive to Chemo & Radiation

Other Names: Ondansetron

Ondansetron blocks serotonin receptors known as 5HT3-receptors. 5HT3-receptors are found in the neurones (nerve cells) of the gastrointestinal system, and also in the area of the brain that controls vomiting. Chemotherapy agents release serotonin from gut cells, which stimulates these receptors and causes vomiting. Ondanestron's blockade of the 5HT3-receptors helps prevent and treat this nausea and vomiting. The mechanism of postoperative nausea and vomiting is not well understood. It is thought to be similar to that of cytotoxic therapy, as Ondansetron is useful in the postoperative setting as well.

Google it: Zofran